Does Deuteronomy 2:25 apply to present-day Jews who reject Christ?

Compared with the way it applied in Deuteronomy, I would say no. In Deuteronomy the fear of God was put into the nations because Israel was about to enter Canaan and destroy those wicked cities. After 400 years of waiting and 40 years in the desert, God was finally bringing judgment on nations even more wicked than the Jews. Israel earned a reputation for slaughtering men, women, children, even animals, and word spread fast. Look at Gideon in Judges: God took him from 32,000 men down to 300, who came at night with lanterns, surprised the sleeping city, and put them to the sword. That is the fear of God, and it traveled from city to city. As for the Jews today, Luke 21:24 says the Gentiles will tread upon Jerusalem until the end of the age. So it is the Gentile period now, and it stays that way until Jesus comes back. There is no rise of Israel, no God centering everything on the Jews again; that is political nonsense created by the dispensationalists and the Scofield Reference Bible. The modern nation exists for political reasons after World War II, and because God is still letting the world know the Jews are here while we make one last effort to get them to accept Christ. Jesus said when you see the fig tree in leaf, know that I am at the very doors. The week before the cross he found the fig tree in full leaf but with no fruit, and that represented Israel: a nation flourishing, a big temple, sacrifices, but not a bit of fruit. That is what we see today, a sign that Jesus is about to come back.